Alkylating Derivatives of Vitamin D Hormone for Prostate Cancer PRINCIPAL INVESTIGATOR:

Award Number: W81XWH-13-1-0252 TITLE: Disparate Vitamin D Activity in the Prostate of Men with African Ancestry PRINCIPAL INVESTIGATOR:

and Invited Presentation: Dec 2013 American Association for Cancer Research (AACR)The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, Atlanta, GA.“Vitamin D and prostate Cancer in African-American Men” Abstract and Poster presentation: November 2015 Steroid Research Congress Chicago. “Vitamin D metabolites in prostate tissue and serum from African...

A Candidate Marker of Hormone Refractory Metastatic Prostate Cancer PRINCIPAL INVESTIGATOR:

Highly potent analogues of luteinizing hormone-releasing hormone containing D-phenylalanine nitrogen mustard in position 6.

The nitrogen mustard derivatives of 4-phenylbutyric acid and L-phenylalanine, called chlorambucil (Chl) and melphalan (Mel), respectively, have been incorporated into several peptide hormones, including luteinizing hormone-releasing hormone (LH-RH). The alkylating analogues of LH-RH were prepared by linking Chl, as an N-acyl moiety, to the complete amino acid sequence of agonistic and antagonis...

Short-chain analogs of luteinizing hormone-releasing hormone containing cytotoxic moieties.

Five hexapeptide and heptapeptide analogs of luteinizing hormone-releasing hormone (LH-RH) were synthesized for use as carriers for cytotoxic compounds. These short analogs were expected to enhance target selectivity of the antineoplastic agents linked to them. Native LH-RH-(3-9) and LH-RH-(4-9) containing D-lysine and D-ornithine at position 6 were amidated with ethylamine and acylated on the ...

Constitutive Activation of NF-Κb in Prostate Carcinoma Cells through a Positive Feedback Loop: Implication of Inducible IKK-Related Kinase (Ikki) PRINCIPAL INVESTIGATOR:

s presented at the national meetings: 1. Yemelyanov A., Kobzeva V., Budunova I. Role of IKKi in prostate cancer: A link between inflammation and androgen receptor signaling. Proceedings of AACR, 2007 (abstract # LBA9158). 2. Budunova I. , Yemelyanov A., Gasparian A. Role of IKKs and transcription factor NF-kB in prostate tumorigenesis. P. IMPACT DOD meeting, 2007, Atlanta. Seminars presented by...